BDBM193363 US10526329, Compound 226::US9670204, 226 N-(6-(4-((1H-imidazol-2-yl)methyl)piperazin-1-yl)-2-ethylimidazo[1,2-a]pyridin-3-yl)-4-(4-fluorophenyl)-N-methylthiazol-2-amine

SMILES: CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(Cc2ncc[nH]2)CC1

InChI Key: InChIKey=CHOUEDZBDITYKT-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 193363   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM193363 (US10526329, Compound 226 | US11072611, Compound 22...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(Cc2ncc[nH]2)CC1 Show InChI InChI=1S/C27H29FN8S/c1-3-22-26(33(2)27-32-23(18-37-27)19-4-6-20(28)7-5-19)36-16-21(8-9-25(36)31-22)35-14-12-34(13-15-35)17-24-29-10-11-30-24/h4-11,16,18H,3,12-15,17H2,1-2H3,(H,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	8.5	25
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate. 5 μL of a di...				US Patent US9670204 (2017) BindingDB Entry DOI: 10.7270/Q2W66HZS
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM193363 (US10526329, Compound 226 | US11072611, Compound 22...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(Cc2ncc[nH]2)CC1 Show InChI InChI=1S/C27H29FN8S/c1-3-22-26(33(2)27-32-23(18-37-27)19-4-6-20(28)7-5-19)36-16-21(8-9-25(36)31-22)35-14-12-34(13-15-35)17-24-29-10-11-30-24/h4-11,16,18H,3,12-15,17H2,1-2H3,(H,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France. Curated by ChEMBL					Assay Description Inhibition of glycosylated human ATX using LPC 16:0 as substrate after 30 mins by luminescence assay				J Med Chem 60: 7371-7392 (2017) Article DOI: 10.1021/acs.jmedchem.7b00647 BindingDB Entry DOI: 10.7270/Q2R213VZ
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM193363 (US10526329, Compound 226 | US11072611, Compound 22...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(Cc2ncc[nH]2)CC1 Show InChI InChI=1S/C27H29FN8S/c1-3-22-26(33(2)27-32-23(18-37-27)19-4-6-20(28)7-5-19)36-16-21(8-9-25(36)31-22)35-14-12-34(13-15-35)17-24-29-10-11-30-24/h4-11,16,18H,3,12-15,17H2,1-2H3,(H,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM193363 (US10526329, Compound 226 | US11072611, Compound 22...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(Cc2ncc[nH]2)CC1 Show InChI InChI=1S/C27H29FN8S/c1-3-22-26(33(2)27-32-23(18-37-27)19-4-6-20(28)7-5-19)36-16-21(8-9-25(36)31-22)35-14-12-34(13-15-35)17-24-29-10-11-30-24/h4-11,16,18H,3,12-15,17H2,1-2H3,(H,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...				US Patent US10526329 (2020) BindingDB Entry DOI: 10.7270/Q2Z60RGR
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM193363 (US10526329, Compound 226 | US11072611, Compound 22...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(Cc2ncc[nH]2)CC1 Show InChI InChI=1S/C27H29FN8S/c1-3-22-26(33(2)27-32-23(18-37-27)19-4-6-20(28)7-5-19)36-16-21(8-9-25(36)31-22)35-14-12-34(13-15-35)17-24-29-10-11-30-24/h4-11,16,18H,3,12-15,17H2,1-2H3,(H,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM193363 (US10526329, Compound 226 | US11072611, Compound 22...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(Cc2ncc[nH]2)CC1 Show InChI InChI=1S/C27H29FN8S/c1-3-22-26(33(2)27-32-23(18-37-27)19-4-6-20(28)7-5-19)36-16-21(8-9-25(36)31-22)35-14-12-34(13-15-35)17-24-29-10-11-30-24/h4-11,16,18H,3,12-15,17H2,1-2H3,(H,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent									US Patent US10526329 (2020) BindingDB Entry DOI: 10.7270/Q2Z60RGR
					More data for this Ligand-Target Pair