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SMILES: Cn1nccc1Nc1cc(ccn1)-c1ccn2c(Cc3ccc(F)cc3F)nnc2c1

InChI Key: InChIKey=MMJZQFMLRKUYMU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193387   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 1 [8-360]


(Homo sapiens (Human))		BDBM193387
PNG
(US9670208, Example 84)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(Cc3ccc(F)cc3F)nnc2c1
Show InChI InChI=1S/C22H17F2N7/c1-30-20(5-8-26-30)27-19-10-14(4-7-25-19)15-6-9-31-21(11-15)28-29-22(31)12-16-2-3-17(23)13-18(16)24/h2-11,13H,12H2,1H3,(H,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...

US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair