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SMILES: C(c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1)c1ccccn1

InChI Key: InChIKey=NZIFNDYFESFOAP-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193672   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 1 [8-360]


(Homo sapiens (Human))		BDBM193672
PNG
(US9670208, Example 278 4-(3-(pyridin-2-ylmethyl)-[...)
Show SMILES C(c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1)c1ccccn1
Show InChI InChI=1S/C21H21N7O/c1-2-8-22-17(3-1)14-20-27-26-19-13-15(5-10-28(19)20)18-4-9-23-21(25-18)24-16-6-11-29-12-7-16/h1-5,8-10,13,16H,6-7,11-12,14H2,(H,23,24,25)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...

US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair