BDBM194218 US9200001, 134

SMILES: Cc1nc(C)n(n1)-c1cc(nc(n1)N1CC[C@@H](F)C1)[C@@H]1C[C@H]1c1nc2ccccc2n1C

InChI Key: InChIKey=JVNSJOMOSKNWOV-BRWVUGGUSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 194218   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM194218 (US9200001, 134) Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CC[C@@H](F)C1)[C@@H]1C[C@H]1c1nc2ccccc2n1C |r| Show InChI InChI=1S/C23H25FN8/c1-13-25-14(2)32(29-13)21-11-19(27-23(28-21)31-9-8-15(24)12-31)16-10-17(16)22-26-18-6-4-5-7-20(18)30(22)3/h4-7,11,15-17H,8-10,12H2,1-3H3/t15-,16-,17-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.580	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...				US Patent US9200001 (2015) BindingDB Entry DOI: 10.7270/Q2BP01M3
					More data for this Ligand-Target Pair