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SMILES: COc1cc2cncc(Cc3ccc4nc(C)ccc4c3)c2cc1OC

InChI Key: InChIKey=VCNMQPNMKKHPTJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 194366   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM194366
PNG
(US9200016, 48)
Show SMILES COc1cc2cncc(Cc3ccc4nc(C)ccc4c3)c2cc1OC
Show InChI InChI=1S/C22H20N2O2/c1-14-4-6-16-8-15(5-7-20(16)24-14)9-17-12-23-13-18-10-21(25-2)22(26-3)11-19(17)18/h4-8,10-13H,9H2,1-3H3
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Similars
US Patent
n/an/a 6.5n/an/an/an/a7.437



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....

US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair