BDBM194969 US9206198, 24

SMILES: Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN(C2)C2=CC(=O)OC2)CC1

InChI Key: InChIKey=WMHOEEFNQVFBRW-NRFANRHFSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 194969   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194969 (US9206198, 24) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN(C2)C2=CC(=O)OC2)CC1 |r,t:26| Show InChI InChI=1S/C24H30N2O5/c1-16-18(3-4-19-20(16)14-31-23(19)29)21(27)12-25-9-6-24(7-10-25)5-2-8-26(15-24)17-11-22(28)30-13-17/h3-4,11,21,27H,2,5-10,12-15H2,1H3/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	620	n/a	n/a	n/a	n/a	7.4	37
Merck Sharp & Dohme Corp. US Patent					Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM194969 (US9206198, 24) Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCCN(C2)C2=CC(=O)OC2)CC1 |r,t:26| Show InChI InChI=1S/C24H30N2O5/c1-16-18(3-4-19-20(16)14-31-23(19)29)21(27)12-25-9-6-24(7-10-25)5-2-8-26(15-24)17-11-22(28)30-13-17/h3-4,11,21,27H,2,5-10,12-15H2,1H3/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	37
Merck Sharp & Dohme Corp. US Patent					Assay Description The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D...				US Patent US9206198 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86FH
					More data for this Ligand-Target Pair