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SMILES: ONC(=O)c1nn(-c2ccc(Oc3ccccc3)cc2)c2ccccc12

InChI Key: InChIKey=MTPNUPIJFRGYKP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 196481   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM196481 (US10202344, Compound 146 | US9212139, 146) Show SMILES ONC(=O)c1nn(-c2ccc(Oc3ccccc3)cc2)c2ccccc12 Show InChI InChI=1S/C20H15N3O3/c24-20(22-25)19-17-8-4-5-9-18(17)23(21-19)14-10-12-16(13-11-14)26-15-6-2-1-3-7-15/h1-13,25H,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma L.P. US Patent					Assay Description Recombinant Nav1.7 Cell Line: In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN...				US Patent US10202344 (2019) BindingDB Entry DOI: 10.7270/Q2X350KJ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM196481 (US10202344, Compound 146 | US9212139, 146) Show SMILES ONC(=O)c1nn(-c2ccc(Oc3ccccc3)cc2)c2ccccc12 Show InChI InChI=1S/C20H15N3O3/c24-20(22-25)19-17-8-4-5-9-18(17)23(21-19)14-10-12-16(13-11-14)26-15-6-2-1-3-7-15/h1-13,25H,(H,22,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.07E+3	n/a	n/a	n/a	n/a	7.3	n/a
Purdue Pharma, L.P. US Patent					Assay Description Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...				US Patent US9212139 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W19
					More data for this Ligand-Target Pair