BDBM196733 US9212173, 11

SMILES: CCn1cnnc1C(C)(C)n1cc(Nc2ncc(c(NC)n2)C(F)(F)F)c(Cl)n1

InChI Key: InChIKey=KPTOLRMQUATBPO-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196733   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM196733 (US9212173, 11) Show SMILES CCn1cnnc1C(C)(C)n1cc(Nc2ncc(c(NC)n2)C(F)(F)F)c(Cl)n1 Show InChI InChI=1S/C16H19ClF3N9/c1-5-28-8-23-26-13(28)15(2,3)29-7-10(11(17)27-29)24-14-22-6-9(16(18,19)20)12(21-4)25-14/h6-8H,5H2,1-4H3,(H2,21,22,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	155	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...				US Patent US9212173 (2015) BindingDB Entry DOI: 10.7270/Q2222SKT
					More data for this Ligand-Target Pair