BDBM19674 (2S)-N-[(1S)-1-cyclopropyl-2-{[4-(trifluoromethoxy)phenyl]amino}ethyl]-4-(morpholin-4-yl)-4-oxo-2-[4-(trifluoromethyl)phenyl]butanamide::succinamide peptidomimetic, 40

SMILES: FC(F)(F)Oc1ccc(NC[C@@H](NC(=O)[C@@H](CC(=O)N2CCOCC2)c2ccc(cc2)C(F)(F)F)C2CC2)cc1

InChI Key: InChIKey=SCMZSMNINRMDKK-XZOQPEGZSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin S (Homo sapiens (Human))	BDBM19674 ((2S)-N-[(1S)-1-cyclopropyl-2-{[4-(trifluoromethoxy...) Show SMILES FC(F)(F)Oc1ccc(NC[C@@H](NC(=O)[C@@H](CC(=O)N2CCOCC2)c2ccc(cc2)C(F)(F)F)C2CC2)cc1 |r| Show InChI InChI=1S/C27H29F6N3O4/c28-26(29,30)19-5-3-17(4-6-19)22(15-24(37)36-11-13-39-14-12-36)25(38)35-23(18-1-2-18)16-34-20-7-9-21(10-8-20)40-27(31,32)33/h3-10,18,22-23,34H,1-2,11-16H2,(H,35,38)/t22-,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	616	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 17: 2899-903 (2007) Article DOI: 10.1016/j.bmcl.2007.02.049 BindingDB Entry DOI: 10.7270/Q2K64GBR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19674 ((2S)-N-[(1S)-1-cyclopropyl-2-{[4-(trifluoromethoxy...) Show SMILES FC(F)(F)Oc1ccc(NC[C@@H](NC(=O)[C@@H](CC(=O)N2CCOCC2)c2ccc(cc2)C(F)(F)F)C2CC2)cc1 |r| Show InChI InChI=1S/C27H29F6N3O4/c28-26(29,30)19-5-3-17(4-6-19)22(15-24(37)36-11-13-39-14-12-36)25(38)35-23(18-1-2-18)16-34-20-7-9-21(10-8-20)40-27(31,32)33/h3-10,18,22-23,34H,1-2,11-16H2,(H,35,38)/t22-,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 17: 2899-903 (2007) Article DOI: 10.1016/j.bmcl.2007.02.049 BindingDB Entry DOI: 10.7270/Q2K64GBR
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19674 ((2S)-N-[(1S)-1-cyclopropyl-2-{[4-(trifluoromethoxy...) Show SMILES FC(F)(F)Oc1ccc(NC[C@@H](NC(=O)[C@@H](CC(=O)N2CCOCC2)c2ccc(cc2)C(F)(F)F)C2CC2)cc1 |r| Show InChI InChI=1S/C27H29F6N3O4/c28-26(29,30)19-5-3-17(4-6-19)22(15-24(37)36-11-13-39-14-12-36)25(38)35-23(18-1-2-18)16-34-20-7-9-21(10-8-20)40-27(31,32)33/h3-10,18,22-23,34H,1-2,11-16H2,(H,35,38)/t22-,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 17: 2899-903 (2007) Article DOI: 10.1016/j.bmcl.2007.02.049 BindingDB Entry DOI: 10.7270/Q2K64GBR
					More data for this Ligand-Target Pair