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BDBM196820 US9212186, 13::US9212186, 14

SMILES: CCNc1nc(Nc2cnn3CCOC(C)c23)ncc1C(F)(F)F

InChI Key: InChIKey=OKNQEWAOCLIHFE-UHFFFAOYNA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 196820   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM196820
PNG
(US9212186, 13 | US9212186, 14)
Show SMILES CCNc1nc(Nc2cnn3CCOC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1/C14H17F3N6O/c1-3-18-12-9(14(15,16)17)6-19-13(22-12)21-10-7-20-23-4-5-24-8(2)11(10)23/h6-8H,3-5H2,1-2H3,(H2,18,19,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1.20n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...


US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM196820
PNG
(US9212186, 13 | US9212186, 14)
Show SMILES CCNc1nc(Nc2cnn3CCOC(C)c23)ncc1C(F)(F)F
Show InChI InChI=1/C14H17F3N6O/c1-3-18-12-9(14(15,16)17)6-19-13(22-12)21-10-7-20-23-4-5-24-8(2)11(10)23/h6-8H,3-5H2,1-2H3,(H2,18,19,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
47.7n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...


US Patent US9212186 (2015)


BindingDB Entry DOI: 10.7270/Q2NS0SPX
More data for this
Ligand-Target Pair