null

SMILES: C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H]1CCCO1

InChI Key: InChIKey=JZPVDDNAUOMUOJ-ORYQWCPZSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19707   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin S (Homo sapiens (Human))	BDBM19707 ((2S)-3-cyclohexyl-2-[(2R)-oxolan-2-ylformamido]-N-...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H]1CCCO1 |r| Show InChI InChI=1S/C24H34F3N3O4/c1-16(15-28-18-9-11-19(12-10-18)34-24(25,26)27)29-22(31)20(14-17-6-3-2-4-7-17)30-23(32)21-8-5-13-33-21/h9-12,16-17,20-21,28H,2-8,13-15H2,1H3,(H,29,31)(H,30,32)/t16-,20-,21+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	18	-11.0	n/a	n/a	n/a	n/a	n/a	5.5	37
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5112-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.033 BindingDB Entry DOI: 10.7270/Q29P2ZXR
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19707 ((2S)-3-cyclohexyl-2-[(2R)-oxolan-2-ylformamido]-N-...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H]1CCCO1 |r| Show InChI InChI=1S/C24H34F3N3O4/c1-16(15-28-18-9-11-19(12-10-18)34-24(25,26)27)29-22(31)20(14-17-6-3-2-4-7-17)30-23(32)21-8-5-13-33-21/h9-12,16-17,20-21,28H,2-8,13-15H2,1H3,(H,29,31)(H,30,32)/t16-,20-,21+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	582	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5112-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.033 BindingDB Entry DOI: 10.7270/Q29P2ZXR
					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM19707 ((2S)-3-cyclohexyl-2-[(2R)-oxolan-2-ylformamido]-N-...) Show SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H]1CCCO1 |r| Show InChI InChI=1S/C24H34F3N3O4/c1-16(15-28-18-9-11-19(12-10-18)34-24(25,26)27)29-22(31)20(14-17-6-3-2-4-7-17)30-23(32)21-8-5-13-33-21/h9-12,16-17,20-21,28H,2-8,13-15H2,1H3,(H,29,31)(H,30,32)/t16-,20-,21+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GNF					Assay Description The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...				Bioorg Med Chem Lett 16: 5112-7 (2006) Article DOI: 10.1016/j.bmcl.2006.07.033 BindingDB Entry DOI: 10.7270/Q29P2ZXR
					More data for this Ligand-Target Pair