BDBM19762 (2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-2-[2-(4-chlorophenoxy)-2-methylpropanamido]-4-methylpentanamide::dipeptidyl nitrile, 16c

SMILES: CC(C)C[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)C(=O)N[C@@H](COCc1ccccc1)C#N

InChI Key: InChIKey=AMJZLJJCJXONIE-GGAORHGYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19762   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cathepsin K (Homo sapiens (Human))	BDBM19762 ((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-2-[2-(4-c...) Show SMILES CC(C)C[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)C(=O)N[C@@H](COCc1ccccc1)C#N |r| Show InChI InChI=1S/C26H32ClN3O4/c1-18(2)14-23(30-25(32)26(3,4)34-22-12-10-20(27)11-13-22)24(31)29-21(15-28)17-33-16-19-8-6-5-7-9-19/h5-13,18,21,23H,14,16-17H2,1-4H3,(H,29,31)(H,30,32)/t21-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.0	22
Novartis Pharmaceuticals					Assay Description The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...				Bioorg Med Chem Lett 16: 2549-54 (2006) Article DOI: 10.1016/j.bmcl.2006.01.104 BindingDB Entry DOI: 10.7270/Q2XG9PFB
					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19762 ((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-2-[2-(4-c...) Show SMILES CC(C)C[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)C(=O)N[C@@H](COCc1ccccc1)C#N |r| Show InChI InChI=1S/C26H32ClN3O4/c1-18(2)14-23(30-25(32)26(3,4)34-22-12-10-20(27)11-13-22)24(31)29-21(15-28)17-33-16-19-8-6-5-7-9-19/h5-13,18,21,23H,14,16-17H2,1-4H3,(H,29,31)(H,30,32)/t21-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Pharmaceuticals					Assay Description The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...				Bioorg Med Chem Lett 16: 2549-54 (2006) Article DOI: 10.1016/j.bmcl.2006.01.104 BindingDB Entry DOI: 10.7270/Q2XG9PFB
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19762 ((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-2-[2-(4-c...) Show SMILES CC(C)C[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)C(=O)N[C@@H](COCc1ccccc1)C#N |r| Show InChI InChI=1S/C26H32ClN3O4/c1-18(2)14-23(30-25(32)26(3,4)34-22-12-10-20(27)11-13-22)24(31)29-21(15-28)17-33-16-19-8-6-5-7-9-19/h5-13,18,21,23H,14,16-17H2,1-4H3,(H,29,31)(H,30,32)/t21-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<30	n/a	n/a	n/a	n/a	5.5	22
Novartis Pharmaceuticals					Assay Description The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...				Bioorg Med Chem Lett 16: 2549-54 (2006) Article DOI: 10.1016/j.bmcl.2006.01.104 BindingDB Entry DOI: 10.7270/Q2XG9PFB
					More data for this Ligand-Target Pair