null

SMILES: Fc1ccc(NS(=O)(=O)c2occc2C2OCCO2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12

InChI Key: InChIKey=FSKBDHVRFZLKSB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 197695   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM197695 (US9216981, 24) Show SMILES Fc1ccc(NS(=O)(=O)c2occc2C2OCCO2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C23H17F2N7O5S/c24-14-3-4-15(32-38(33,34)23-13(5-7-37-23)22-35-8-9-36-22)16(25)18(14)31-20-12(2-1-6-26-20)17-19-21(29-10-27-17)30-11-28-19/h1-7,10-11,22,32H,8-9H2,(H,26,31)(H,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	800	n/a	n/a	n/a	37
Medpacto, Inc. US Patent					Assay Description To check the B-Raf cell activity inhibitory capability of the compounds of the present invention, the following experiments were conducted in A375P...				US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM197695 (US9216981, 24) Show SMILES Fc1ccc(NS(=O)(=O)c2occc2C2OCCO2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C23H17F2N7O5S/c24-14-3-4-15(32-38(33,34)23-13(5-7-37-23)22-35-8-9-36-22)16(25)18(14)31-20-12(2-1-6-26-20)17-19-21(29-10-27-17)30-11-28-19/h1-7,10-11,22,32H,8-9H2,(H,26,31)(H,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	220	n/a	n/a	n/a	n/a	7.2	30
Medpacto, Inc. US Patent					Assay Description To check the B-Raf kinase inhibitory activity of the compounds of the present invention, the following experiments were conducted.(1) Serial Signalin...				US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR
					More data for this Ligand-Target Pair