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SMILES: COc1ccc(C)n2nc(CCc3cc(OC)c4ccccc4n3)nc12

InChI Key: InChIKey=MOCHHWZVRUMXSG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 197745   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM197745 (US9216986, 4-Methoxy-2-[2-(8-methoxy-5-methyl-[1,2...) Show SMILES COc1ccc(C)n2nc(CCc3cc(OC)c4ccccc4n3)nc12 Show InChI InChI=1S/C20H20N4O2/c1-13-8-10-17(25-2)20-22-19(23-24(13)20)11-9-14-12-18(26-3)15-6-4-5-7-16(15)21-14/h4-8,10,12H,9,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9801878 (2017) BindingDB Entry DOI: 10.7270/Q26Q20CD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM197745 (US9216986, 4-Methoxy-2-[2-(8-methoxy-5-methyl-[1,2...) Show SMILES COc1ccc(C)n2nc(CCc3cc(OC)c4ccccc4n3)nc12 Show InChI InChI=1S/C20H20N4O2/c1-13-8-10-17(25-2)20-22-19(23-24(13)20)11-9-14-12-18(26-3)15-6-4-5-7-16(15)21-14/h4-8,10,12H,9,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9216986 (2015) BindingDB Entry DOI: 10.7270/Q2Z31XG5
					More data for this Ligand-Target Pair