BDBM197758 US9216986, 2-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-6-fluoro-4-methoxy-quinoline::US9801878, 2-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-6-fluoro-4-methoxy-quinoline
SMILES: COc1cc(CCc2nc3c(C)ncc(C)n3n2)nc2ccc(F)cc12
InChI Key: InChIKey=RVNLAISERMFIRL-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM197758 (US9216986, 2-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme... | US Patent US9801878 (2017) BindingDB Entry DOI: 10.7270/Q26Q20CD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PED10A (Homo sapiens (Human)) | BDBM197758 (US9216986, 2-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | 25 |
H. Lundbeck A/S US Patent | Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme... | US Patent US9216986 (2015) BindingDB Entry DOI: 10.7270/Q2Z31XG5 | |||||||||||
More data for this Ligand-Target Pair |