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SMILES: Cc1ncc(C)n2nc(CCc3ccc4ccc(Cl)cc4n3)nc12

InChI Key: InChIKey=FATJBQNFQIWTPW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 197762   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM197762 (US9216986, 7-Chloro-2-[2-(5,8-dimethyl-[1,2,4]tria...) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccc(Cl)cc4n3)nc12 Show InChI InChI=1S/C18H16ClN5/c1-11-10-20-12(2)18-22-17(23-24(11)18)8-7-15-6-4-13-3-5-14(19)9-16(13)21-15/h3-6,9-10H,7-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9801878 (2017) BindingDB Entry DOI: 10.7270/Q26Q20CD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] (Homo sapiens (Human))	BDBM197762 (US9216986, 7-Chloro-2-[2-(5,8-dimethyl-[1,2,4]tria...) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccc(Cl)cc4n3)nc12 Show InChI InChI=1S/C18H16ClN5/c1-11-10-20-12(2)18-22-17(23-24(11)18)8-7-15-6-4-13-3-5-14(19)9-16(13)21-15/h3-6,9-10H,7-8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9216986 (2015) BindingDB Entry DOI: 10.7270/Q2Z31XG5
					More data for this Ligand-Target Pair