BDBM197777 US9216986, 2-[(E)-2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-vinyl]-6-trifluoromethoxy-quinoline

SMILES: Cc1cnc(C)c2nc(\C=C\c3ccc4cc(OC(F)(F)F)ccc4n3)nn12

InChI Key: InChIKey=UNADFJGCAZZCNL-VMPITWQZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 197777   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PED10A (Homo sapiens (Human))	BDBM197777 (US9216986, 2-[(E)-2-(5,8-Dimethyl-[1,2,4]triazolo[...) Show SMILES Cc1cnc(C)c2nc(\C=C\c3ccc4cc(OC(F)(F)F)ccc4n3)nn12 Show InChI InChI=1S/C19H14F3N5O/c1-11-10-23-12(2)18-25-17(26-27(11)18)8-5-14-4-3-13-9-15(28-19(20,21)22)6-7-16(13)24-14/h3-10H,1-2H3/b8-5+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9216986 (2015) BindingDB Entry DOI: 10.7270/Q2Z31XG5
					More data for this Ligand-Target Pair