BDBM198120 TSA
SMILES: CC(\C=C\C(=O)NO)\C=C(/C)C(=O)c1ccc(cc1)N(C)C
InChI Key: InChIKey=ALCVRKZFLFWUAZ-VFIIPLLCSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 6 [440-798] (Danio rerio) | BDBM198120 (TSA) | UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.800 | -12.4 | 1.40 | n/a | n/a | n/a | n/a | n/a | 25 |
University of Pennsylvania, | Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using... | Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 [84-835] (Homo sapiens (Human)) | BDBM198120 (TSA) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.20 | -11.8 | 3.90 | n/a | n/a | n/a | n/a | n/a | 25 |
University of Pennsylvania, | Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using... | Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 [60-420] (Danio rerio) | BDBM198120 (TSA) | UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 4.80 | -11.3 | 7 | n/a | n/a | n/a | n/a | n/a | 25 |
University of Pennsylvania, | Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using... | Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1 | |||||||||||
More data for this Ligand-Target Pair |