BDBM198912 US9221802, Ref. Ex. 79::US9315498, 79

SMILES: CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)cc1

InChI Key: InChIKey=KLMGMSFWQGMDTB-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 198912   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198912 (US9221802, Ref. Ex. 79 | US9315498, 79) Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)cc1 Show InChI InChI=1S/C19H17FN2O2/c1-19(2)11-12-22(18(23)24-19)17-10-7-15(13-21-17)4-3-14-5-8-16(20)9-6-14/h5-10,13H,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	37
HOFFMAN-LA ROCHE INC. US Patent					Assay Description A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...				US Patent US9315498 (2016) BindingDB Entry DOI: 10.7270/Q23T9G2X
					More data for this Ligand-Target Pair
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human))	BDBM198912 (US9221802, Ref. Ex. 79 | US9315498, 79) Show SMILES CC1(C)CCN(C(=O)O1)c1ccc(cn1)C#Cc1ccc(F)cc1 Show InChI InChI=1S/C19H17FN2O2/c1-19(2)11-12-22(18(23)24-19)17-10-7-15(13-21-17)4-3-14-5-8-16(20)9-6-14/h5-10,13H,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	37
Hoffman-La Roche Inc. US Patent					Assay Description About 24 hrs before an experiment, 5x104 cells/well were seeded in poly-D-lysine coated, black/clear-bottomed 96-well plates. The cells were loaded...				US Patent US9221802 (2015) BindingDB Entry DOI: 10.7270/Q2RF5SVJ
					More data for this Ligand-Target Pair