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SMILES: FC(F)(F)c1c(CCc2ccccc2)n2CCN(Cc3cccc1c23)C(=O)Nc1ccccc1

InChI Key: InChIKey=ZDJWTQWMWCXPCQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 199210   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Mus musculus (Mouse))	BDBM199210 (US9216998, 14) Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCN(Cc3cccc1c23)C(=O)Nc1ccccc1 Show InChI InChI=1S/C27H24F3N3O/c28-27(29,30)24-22-13-7-10-20-18-32(26(34)31-21-11-5-2-6-12-21)16-17-33(25(20)22)23(24)15-14-19-8-3-1-4-9-19/h1-13H,14-18H2,(H,31,34)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	162	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM199210 (US9216998, 14) Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCN(Cc3cccc1c23)C(=O)Nc1ccccc1 Show InChI InChI=1S/C27H24F3N3O/c28-27(29,30)24-22-13-7-10-20-18-32(26(34)31-21-11-5-2-6-12-21)16-17-33(25(20)22)23(24)15-14-19-8-3-1-4-9-19/h1-13H,14-18H2,(H,31,34)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	168	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair