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SMILES: Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12

InChI Key: InChIKey=IOHAAGRRFZIREZ-LJQANCHMSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 200327   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proprotein convertase subtilisin/kexin type 9 (Homo sapiens (Human))	BDBM200327 (US9227956, 12) Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12 |r| Show InChI InChI=1S/C25H26N6O3/c1-29-13-10-17-9-12-27-23(21(17)29)31(19-4-3-11-26-14-19)24(32)18-7-5-16(6-8-18)20-15-28-30(2)22(20)25(33)34/h5-10,12-13,15,19,26H,3-4,11,14H2,1-2H3,(H,33,34)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (Homo sapiens (Human))	BDBM200327 (US9227956, 12) Show SMILES Cn1ncc(c1C(O)=O)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12 |r| Show InChI InChI=1S/C25H26N6O3/c1-29-13-10-17-9-12-27-23(21(17)29)31(19-4-3-11-26-14-19)24(32)18-7-5-16(6-8-18)20-15-28-30(2)22(20)25(33)34/h5-10,12-13,15,19,26H,3-4,11,14H2,1-2H3,(H,33,34)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair