Found 5 hits for monomerid = 200517 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
B-RAF V600E
(Homo sapiens (Human)) | BDBM200517
(US9670231, 1.39)Show SMILES Fc1cccc(c1)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C24H18FN3O4/c25-13-3-1-2-12(10-13)24(30)28-21-20-16-11-14(4-6-17(16)32-22(20)21)31-18-8-9-26-23-15(18)5-7-19(29)27-23/h1-4,6,8-11,20-22H,5,7H2,(H,28,30)(H,26,27,29)/t20-,21-,22-/m0/s1 | PDB
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description
TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM200517
(US9670231, 1.39)Show SMILES Fc1cccc(c1)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C24H18FN3O4/c25-13-3-1-2-12(10-13)24(30)28-21-20-16-11-14(4-6-17(16)32-22(20)21)31-18-8-9-26-23-15(18)5-7-19(29)27-23/h1-4,6,8-11,20-22H,5,7H2,(H,28,30)(H,26,27,29)/t20-,21-,22-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description
TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor(L858R, T790M)
(Homo sapiens (Human)) | BDBM200517
(US9670231, 1.39)Show SMILES Fc1cccc(c1)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C24H18FN3O4/c25-13-3-1-2-12(10-13)24(30)28-21-20-16-11-14(4-6-17(16)32-22(20)21)31-18-8-9-26-23-15(18)5-7-19(29)27-23/h1-4,6,8-11,20-22H,5,7H2,(H,28,30)(H,26,27,29)/t20-,21-,22-/m0/s1 | PDB
MMDB
KEGG
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 692 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description
TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor(L858R)
(Homo sapiens (Human)) | BDBM200517
(US9670231, 1.39)Show SMILES Fc1cccc(c1)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C24H18FN3O4/c25-13-3-1-2-12(10-13)24(30)28-21-20-16-11-14(4-6-17(16)32-22(20)21)31-18-8-9-26-23-15(18)5-7-19(29)27-23/h1-4,6,8-11,20-22H,5,7H2,(H,28,30)(H,26,27,29)/t20-,21-,22-/m0/s1 | PDB
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description
TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM200517
(US9670231, 1.39)Show SMILES Fc1cccc(c1)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C24H18FN3O4/c25-13-3-1-2-12(10-13)24(30)28-21-20-16-11-14(4-6-17(16)32-22(20)21)31-18-8-9-26-23-15(18)5-7-19(29)27-23/h1-4,6,8-11,20-22H,5,7H2,(H,28,30)(H,26,27,29)/t20-,21-,22-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description
TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this
Ligand-Target Pair | |
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