BDBM200602 US10011604, 28::US10590139, Example 28::US9227975, 28::US9796723, 28

SMILES: CNC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key: InChIKey=DQANMQMIIOKILD-CQSZACIVSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 200602   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM200602 (US10011604, 28 | US10590139, Example 28 | US922797...) Show SMILES CNC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H18F2N6O/c1-21-18(27)23-17-10-22-15-6-7-16(24-26(15)17)25-8-2-3-14(25)12-9-11(19)4-5-13(12)20/h4-7,9-10,14H,2-3,8H2,1H3,(H2,21,23,27)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65.7	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9227975 (2016) BindingDB Entry DOI: 10.7270/Q2GQ6WKV
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM200602 (US10011604, 28 | US10590139, Example 28 | US922797...) Show SMILES CNC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H18F2N6O/c1-21-18(27)23-17-10-22-15-6-7-16(24-26(15)17)25-8-2-3-14(25)12-9-11(19)4-5-13(12)20/h4-7,9-10,14H,2-3,8H2,1H3,(H2,21,23,27)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65.7	n/a	n/a	n/a	n/a	n/a	n/a
Otsuka Pharmaceutical Co., Ltd					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 7: 1743-54 BindingDB Entry DOI: 10.7270/Q2RB76ZK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM200602 (US10011604, 28 | US10590139, Example 28 | US922797...) Show SMILES CNC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H18F2N6O/c1-21-18(27)23-17-10-22-15-6-7-16(24-26(15)17)25-8-2-3-14(25)12-9-11(19)4-5-13(12)20/h4-7,9-10,14H,2-3,8H2,1H3,(H2,21,23,27)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65.7	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10590139 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM200602 (US10011604, 28 | US10590139, Example 28 | US922797...) Show SMILES CNC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H18F2N6O/c1-21-18(27)23-17-10-22-15-6-7-16(24-26(15)17)25-8-2-3-14(25)12-9-11(19)4-5-13(12)20/h4-7,9-10,14H,2-3,8H2,1H3,(H2,21,23,27)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65.7	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9796723 (2017) BindingDB Entry DOI: 10.7270/Q2CC12SB
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM200602 (US10011604, 28 | US10590139, Example 28 | US922797...) Show SMILES CNC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H18F2N6O/c1-21-18(27)23-17-10-22-15-6-7-16(24-26(15)17)25-8-2-3-14(25)12-9-11(19)4-5-13(12)20/h4-7,9-10,14H,2-3,8H2,1H3,(H2,21,23,27)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65.7	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9795611 (2017) BindingDB Entry DOI: 10.7270/Q25T3NMH
					More data for this Ligand-Target Pair