BDBM200623 US10011604, 49::US10590139, Example 49::US9227975, 49::US9796723, 49
SMILES: CC(C)[C@H]1CN(CCN1C(=O)OC(C)(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
InChI Key: InChIKey=KIGPOOKMIMVRLZ-DHIUTWEWSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM200623 (US10011604, 49 | US10590139, Example 49 | US922797...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 857 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Array BioPharma, Inc. US Patent | Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... | US Patent US9227975 (2016) BindingDB Entry DOI: 10.7270/Q2GQ6WKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM200623 (US10011604, 49 | US10590139, Example 49 | US922797...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 857 | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co., Ltd | Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and... | Bioorg Med Chem 7: 1743-54 BindingDB Entry DOI: 10.7270/Q2RB76ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM200623 (US10011604, 49 | US10590139, Example 49 | US922797...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 857 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc. US Patent | Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... | US Patent US10590139 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM200623 (US10011604, 49 | US10590139, Example 49 | US922797...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 857 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc. US Patent | Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... | US Patent US9796723 (2017) BindingDB Entry DOI: 10.7270/Q2CC12SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM200623 (US10011604, 49 | US10590139, Example 49 | US922797...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 857 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc. US Patent | Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... | US Patent US9795611 (2017) BindingDB Entry DOI: 10.7270/Q25T3NMH | |||||||||||
More data for this Ligand-Target Pair |