BDBM200626 US10590139, Example 52::US9227975, 52::US9796723, 52

SMILES: OCC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F

InChI Key: InChIKey=GXGABCOHBHOWDE-QGZVFWFLSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 200626   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM200626 (US10590139, Example 52 | US9227975, 52 | US9796723...) Show SMILES OCC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C21H22F2N6O2/c22-14-3-4-16(23)15(8-14)17-2-1-7-28(17)19-6-5-18-24-9-20(29(18)26-19)25-21(31)27-10-13(11-27)12-30/h3-6,8-9,13,17,30H,1-2,7,10-12H2,(H,25,31)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9227975 (2016) BindingDB Entry DOI: 10.7270/Q2GQ6WKV
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM200626 (US10590139, Example 52 | US9227975, 52 | US9796723...) Show SMILES OCC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C21H22F2N6O2/c22-14-3-4-16(23)15(8-14)17-2-1-7-28(17)19-6-5-18-24-9-20(29(18)26-19)25-21(31)27-10-13(11-27)12-30/h3-6,8-9,13,17,30H,1-2,7,10-12H2,(H,25,31)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10590139 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM200626 (US10590139, Example 52 | US9227975, 52 | US9796723...) Show SMILES OCC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C21H22F2N6O2/c22-14-3-4-16(23)15(8-14)17-2-1-7-28(17)19-6-5-18-24-9-20(29(18)26-19)25-21(31)27-10-13(11-27)12-30/h3-6,8-9,13,17,30H,1-2,7,10-12H2,(H,25,31)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9796723 (2017) BindingDB Entry DOI: 10.7270/Q2CC12SB
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM200626 (US10590139, Example 52 | US9227975, 52 | US9796723...) Show SMILES OCC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C21H22F2N6O2/c22-14-3-4-16(23)15(8-14)17-2-1-7-28(17)19-6-5-18-24-9-20(29(18)26-19)25-21(31)27-10-13(11-27)12-30/h3-6,8-9,13,17,30H,1-2,7,10-12H2,(H,25,31)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9795611 (2017) BindingDB Entry DOI: 10.7270/Q25T3NMH
					More data for this Ligand-Target Pair