Found 2 hits for monomerid = 200743 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM200743
(US9233108, 4)Show SMILES CN(CCCn1ccc2cc(CNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)ccc12)[C@H]1CC[C@@H](CC1)OC(=O)C(O)(c1cccs1)c1cccs1 |wU:34.41,wD:14.14,31.34,(6.72,6.42,;5.21,6.1,;4.73,4.64,;5.76,3.5,;5.29,2.03,;6.32,.89,;7.85,1.05,;8.48,-.36,;7.33,-1.39,;7.33,-2.93,;6,-3.7,;6,-5.24,;7.33,-6.01,;7.33,-7.55,;8.67,-8.32,;10,-7.55,;8.67,-9.86,;7.33,-10.63,;7.33,-12.17,;8.67,-12.94,;8.67,-14.48,;10,-12.17,;11.33,-12.94,;12.67,-12.17,;14,-12.94,;12.67,-10.63,;11.33,-9.86,;10,-10.63,;4.67,-2.93,;4.67,-1.39,;6,-.62,;4.18,7.25,;4.66,8.71,;3.62,9.86,;2.12,9.54,;1.64,8.07,;2.67,6.93,;1.09,10.68,;-.42,10.36,;-.89,8.9,;-1.45,11.51,;-.3,12.54,;-2.48,12.65,;-4.01,12.49,;-4.64,13.9,;-3.49,14.93,;-2.16,14.16,;-2.59,10.48,;-2.43,8.94,;-3.84,8.32,;-4.87,9.46,;-4.1,10.8,)| Show InChI InChI=1S/C40H44N4O6S2/c1-43(28-8-10-29(11-9-28)50-39(48)40(49,35-5-2-21-51-35)36-6-3-22-52-36)18-4-19-44-20-17-27-23-26(7-14-32(27)44)24-41-25-34(46)30-12-15-33(45)38-31(30)13-16-37(47)42-38/h2-3,5-7,12-17,20-23,28-29,34,41,45-46,49H,4,8-11,18-19,24-25H2,1H3,(H,42,47)/t28-,29-,34-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
ALMIRALL, S.A.
US Patent
| Assay Description The study of binding to human muscarinic M1, M2, M3, M4 and M5 receptors was performed using commercial membranes (Perkin Elmer) prepared from CHO-K1... |
US Patent US9233108 (2016)
BindingDB Entry DOI: 10.7270/Q23J3BSN |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM200743
(US9233108, 4)Show SMILES CN(CCCn1ccc2cc(CNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)ccc12)[C@H]1CC[C@@H](CC1)OC(=O)C(O)(c1cccs1)c1cccs1 |wU:34.41,wD:14.14,31.34,(6.72,6.42,;5.21,6.1,;4.73,4.64,;5.76,3.5,;5.29,2.03,;6.32,.89,;7.85,1.05,;8.48,-.36,;7.33,-1.39,;7.33,-2.93,;6,-3.7,;6,-5.24,;7.33,-6.01,;7.33,-7.55,;8.67,-8.32,;10,-7.55,;8.67,-9.86,;7.33,-10.63,;7.33,-12.17,;8.67,-12.94,;8.67,-14.48,;10,-12.17,;11.33,-12.94,;12.67,-12.17,;14,-12.94,;12.67,-10.63,;11.33,-9.86,;10,-10.63,;4.67,-2.93,;4.67,-1.39,;6,-.62,;4.18,7.25,;4.66,8.71,;3.62,9.86,;2.12,9.54,;1.64,8.07,;2.67,6.93,;1.09,10.68,;-.42,10.36,;-.89,8.9,;-1.45,11.51,;-.3,12.54,;-2.48,12.65,;-4.01,12.49,;-4.64,13.9,;-3.49,14.93,;-2.16,14.16,;-2.59,10.48,;-2.43,8.94,;-3.84,8.32,;-4.87,9.46,;-4.1,10.8,)| Show InChI InChI=1S/C40H44N4O6S2/c1-43(28-8-10-29(11-9-28)50-39(48)40(49,35-5-2-21-51-35)36-6-3-22-52-36)18-4-19-44-20-17-27-23-26(7-14-32(27)44)24-41-25-34(46)30-12-15-33(45)38-31(30)13-16-37(47)42-38/h2-3,5-7,12-17,20-23,28-29,34,41,45-46,49H,4,8-11,18-19,24-25H2,1H3,(H,42,47)/t28-,29-,34-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | 25 |
ALMIRALL, S.A.
US Patent
| Assay Description The study of binding to human adrenergic beta1 and beta2 receptors was performed using commercial membranes prepared from Sf9 cells where they are ov... |
US Patent US9233108 (2016)
BindingDB Entry DOI: 10.7270/Q23J3BSN |
More data for this Ligand-Target Pair | |