Found 4 hits for monomerid = 200755 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM200755
(US9233108, 20 | US9757383, Example 20)Show SMILES CC(Cc1ccc(OCC(=O)NCCN[C@H]2CC[C@@H](CC2)OC(=O)C(O)(c2cccs2)c2cccs2)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 |wU:18.21,wD:40.44,15.14,(15.73,-2.32,;16.5,-.98,;15.73,.35,;14.19,.35,;13.42,1.69,;11.88,1.69,;11.11,.35,;9.57,.35,;8.8,-.98,;7.26,-.98,;6.49,.35,;6.49,-2.32,;4.95,-2.32,;4.18,-.98,;4.95,.35,;4.18,1.69,;4.95,3.02,;4.18,4.35,;2.64,4.35,;1.87,3.02,;2.64,1.69,;1.87,5.69,;.33,5.69,;-.44,4.35,;-.44,7.02,;.89,7.79,;-1.21,8.35,;-2.74,8.51,;-3.06,10.02,;-1.73,10.79,;-.58,9.76,;-1.77,6.25,;-1.93,4.72,;-3.44,4.4,;-4.21,5.73,;-3.18,6.88,;11.88,-.98,;13.42,-.98,;18.04,-.98,;18.81,-2.32,;20.35,-2.32,;21.12,-.98,;21.12,-3.65,;20.35,-4.98,;21.12,-6.32,;22.66,-6.32,;23.43,-7.65,;23.43,-4.98,;24.97,-4.98,;25.74,-3.65,;27.28,-3.65,;24.97,-2.32,;23.43,-2.32,;22.66,-3.65,)| Show InChI InChI=1S/C40H46N4O8S2/c1-25(43-23-33(46)30-14-16-32(45)38-31(30)15-17-36(47)44-38)22-26-6-10-28(11-7-26)51-24-37(48)42-19-18-41-27-8-12-29(13-9-27)52-39(49)40(50,34-4-2-20-53-34)35-5-3-21-54-35/h2-7,10-11,14-17,20-21,25,27,29,33,41,43,45-46,50H,8-9,12-13,18-19,22-24H2,1H3,(H,42,48)(H,44,47)/t25?,27-,29-,33-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | 25 |
ALMIRALL, S.A.
US Patent
| Assay Description The study of binding to human adrenergic beta1 and beta2 receptors was performed using commercial membranes prepared from Sf9 cells where they are ov... |
US Patent US9233108 (2016)
BindingDB Entry DOI: 10.7270/Q23J3BSN |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM200755
(US9233108, 20 | US9757383, Example 20)Show SMILES CC(Cc1ccc(OCC(=O)NCCN[C@H]2CC[C@@H](CC2)OC(=O)C(O)(c2cccs2)c2cccs2)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 |wU:18.21,wD:40.44,15.14,(15.73,-2.32,;16.5,-.98,;15.73,.35,;14.19,.35,;13.42,1.69,;11.88,1.69,;11.11,.35,;9.57,.35,;8.8,-.98,;7.26,-.98,;6.49,.35,;6.49,-2.32,;4.95,-2.32,;4.18,-.98,;4.95,.35,;4.18,1.69,;4.95,3.02,;4.18,4.35,;2.64,4.35,;1.87,3.02,;2.64,1.69,;1.87,5.69,;.33,5.69,;-.44,4.35,;-.44,7.02,;.89,7.79,;-1.21,8.35,;-2.74,8.51,;-3.06,10.02,;-1.73,10.79,;-.58,9.76,;-1.77,6.25,;-1.93,4.72,;-3.44,4.4,;-4.21,5.73,;-3.18,6.88,;11.88,-.98,;13.42,-.98,;18.04,-.98,;18.81,-2.32,;20.35,-2.32,;21.12,-.98,;21.12,-3.65,;20.35,-4.98,;21.12,-6.32,;22.66,-6.32,;23.43,-7.65,;23.43,-4.98,;24.97,-4.98,;25.74,-3.65,;27.28,-3.65,;24.97,-2.32,;23.43,-2.32,;22.66,-3.65,)| Show InChI InChI=1S/C40H46N4O8S2/c1-25(43-23-33(46)30-14-16-32(45)38-31(30)15-17-36(47)44-38)22-26-6-10-28(11-7-26)51-24-37(48)42-19-18-41-27-8-12-29(13-9-27)52-39(49)40(50,34-4-2-20-53-34)35-5-3-21-54-35/h2-7,10-11,14-17,20-21,25,27,29,33,41,43,45-46,50H,8-9,12-13,18-19,22-24H2,1H3,(H,42,48)(H,44,47)/t25?,27-,29-,33-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Almirall, S.A.
US Patent
| Assay Description The study of binding to human muscarinic M1, M2, M3, M4 and M5 receptors was performed using commercial membranes (Perkin Elmer) prepared from CHO-K1... |
US Patent US9757383 (2017)
BindingDB Entry DOI: 10.7270/Q2HX1FSN |
More data for this Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM200755
(US9233108, 20 | US9757383, Example 20)Show SMILES CC(Cc1ccc(OCC(=O)NCCN[C@H]2CC[C@@H](CC2)OC(=O)C(O)(c2cccs2)c2cccs2)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 |wU:18.21,wD:40.44,15.14,(15.73,-2.32,;16.5,-.98,;15.73,.35,;14.19,.35,;13.42,1.69,;11.88,1.69,;11.11,.35,;9.57,.35,;8.8,-.98,;7.26,-.98,;6.49,.35,;6.49,-2.32,;4.95,-2.32,;4.18,-.98,;4.95,.35,;4.18,1.69,;4.95,3.02,;4.18,4.35,;2.64,4.35,;1.87,3.02,;2.64,1.69,;1.87,5.69,;.33,5.69,;-.44,4.35,;-.44,7.02,;.89,7.79,;-1.21,8.35,;-2.74,8.51,;-3.06,10.02,;-1.73,10.79,;-.58,9.76,;-1.77,6.25,;-1.93,4.72,;-3.44,4.4,;-4.21,5.73,;-3.18,6.88,;11.88,-.98,;13.42,-.98,;18.04,-.98,;18.81,-2.32,;20.35,-2.32,;21.12,-.98,;21.12,-3.65,;20.35,-4.98,;21.12,-6.32,;22.66,-6.32,;23.43,-7.65,;23.43,-4.98,;24.97,-4.98,;25.74,-3.65,;27.28,-3.65,;24.97,-2.32,;23.43,-2.32,;22.66,-3.65,)| Show InChI InChI=1S/C40H46N4O8S2/c1-25(43-23-33(46)30-14-16-32(45)38-31(30)15-17-36(47)44-38)22-26-6-10-28(11-7-26)51-24-37(48)42-19-18-41-27-8-12-29(13-9-27)52-39(49)40(50,34-4-2-20-53-34)35-5-3-21-54-35/h2-7,10-11,14-17,20-21,25,27,29,33,41,43,45-46,50H,8-9,12-13,18-19,22-24H2,1H3,(H,42,48)(H,44,47)/t25?,27-,29-,33-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Almirall, S.A.
US Patent
| Assay Description The study of binding to human adrenergic beta1 and beta2 receptors was performed using commercial membranes prepared from Sf9 cells where they are ov... |
US Patent US9757383 (2017)
BindingDB Entry DOI: 10.7270/Q2HX1FSN |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor M3
(Homo sapiens (Human)) | BDBM200755
(US9233108, 20 | US9757383, Example 20)Show SMILES CC(Cc1ccc(OCC(=O)NCCN[C@H]2CC[C@@H](CC2)OC(=O)C(O)(c2cccs2)c2cccs2)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 |wU:18.21,wD:40.44,15.14,(15.73,-2.32,;16.5,-.98,;15.73,.35,;14.19,.35,;13.42,1.69,;11.88,1.69,;11.11,.35,;9.57,.35,;8.8,-.98,;7.26,-.98,;6.49,.35,;6.49,-2.32,;4.95,-2.32,;4.18,-.98,;4.95,.35,;4.18,1.69,;4.95,3.02,;4.18,4.35,;2.64,4.35,;1.87,3.02,;2.64,1.69,;1.87,5.69,;.33,5.69,;-.44,4.35,;-.44,7.02,;.89,7.79,;-1.21,8.35,;-2.74,8.51,;-3.06,10.02,;-1.73,10.79,;-.58,9.76,;-1.77,6.25,;-1.93,4.72,;-3.44,4.4,;-4.21,5.73,;-3.18,6.88,;11.88,-.98,;13.42,-.98,;18.04,-.98,;18.81,-2.32,;20.35,-2.32,;21.12,-.98,;21.12,-3.65,;20.35,-4.98,;21.12,-6.32,;22.66,-6.32,;23.43,-7.65,;23.43,-4.98,;24.97,-4.98,;25.74,-3.65,;27.28,-3.65,;24.97,-2.32,;23.43,-2.32,;22.66,-3.65,)| Show InChI InChI=1S/C40H46N4O8S2/c1-25(43-23-33(46)30-14-16-32(45)38-31(30)15-17-36(47)44-38)22-26-6-10-28(11-7-26)51-24-37(48)42-19-18-41-27-8-12-29(13-9-27)52-39(49)40(50,34-4-2-20-53-34)35-5-3-21-54-35/h2-7,10-11,14-17,20-21,25,27,29,33,41,43,45-46,50H,8-9,12-13,18-19,22-24H2,1H3,(H,42,48)(H,44,47)/t25?,27-,29-,33-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ALMIRALL, S.A.
US Patent
| Assay Description The study of binding to human muscarinic M1, M2, M3, M4 and M5 receptors was performed using commercial membranes (Perkin Elmer) prepared from CHO-K1... |
US Patent US9233108 (2016)
BindingDB Entry DOI: 10.7270/Q23J3BSN |
More data for this Ligand-Target Pair | |