BDBM200834 2-[5-((2s,3's)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyrazin-2-yl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester::US9533995, 14
SMILES: C[C@H]1CCCN1[C@H]1CCN(C1)c1cnc(cn1)N1CCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O
InChI Key: InChIKey=CDPBGEGOIYXGLM-PMACEKPBSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine receptor H3 (Macaca mulatta (Rhesus macaque)) | BDBM200834 (2-[5-((2s,3's)-2-methyl-[1,3']bipyrrolidin...) | UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi US Patent | Assay Description Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme... | US Patent US9533995 (2017) BindingDB Entry DOI: 10.7270/Q25H7DFS | |||||||||||
More data for this Ligand-Target Pair |