BDBM200836 2-[2-methyl-6-((2s,3's)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyridin-3-yl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester::US9533995, 15

SMILES: C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(C)n1

InChI Key: InChIKey=VWEDTHKZJLWCBY-UNMCSNQZSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 200836   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine receptor H3 (Macaca mulatta (Rhesus macaque))	BDBM200836 (2-[2-methyl-6-((2s,3's)-2-methyl-[1,3']bip...) Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(C)n1 |r| Show InChI InChI=1S/C28H43N5O3/c1-20-7-6-14-32(20)22-10-15-31(19-22)24-9-8-23(21(2)29-24)33-18-13-28(25(33)34)11-16-30(17-12-28)26(35)36-27(3,4)5/h8-9,20,22H,6-7,10-19H2,1-5H3/t20-,22-/m0/s1	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	95.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi US Patent					Assay Description Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...				US Patent US9533995 (2017) BindingDB Entry DOI: 10.7270/Q25H7DFS
					More data for this Ligand-Target Pair