BDBM2017 2-(4-Azaindol-3-yl)-5,11-dihydro-11-ethyl-5-methyl-6Hdipyrido[3,2-b:2 ,3 -e][1,4]diazepin-6-one::2-ethyl-9-methyl-5-{1H-pyrrolo[3,2-b]pyridin-3-yl}-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-10-one::2-indolyl dipyridodiazepinone 7d
SMILES: CCN1c2nc(ccc2N(C)C(=O)c2cccnc12)-c1c[nH]c2cccnc12
InChI Key: InChIKey=HUDKKUOYZHDRQE-UHFFFAOYSA-N
Data: 3 Other
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2017 (2-(4-Azaindol-3-yl)-5,11-dihydro-11-ethyl-5-methyl...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 40: 2430-3 (1997) Article DOI: 10.1021/jm960837y BindingDB Entry DOI: 10.7270/Q2P26W9K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase Mutant (Y188L) (Human immunodeficiency virus type 1) | BDBM2017 (2-(4-Azaindol-3-yl)-5,11-dihydro-11-ethyl-5-methyl...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 40: 2430-3 (1997) Article DOI: 10.1021/jm960837y BindingDB Entry DOI: 10.7270/Q2P26W9K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HIV-1 Reverse Transcriptase Mutant (Y181C) (Human immunodeficiency virus type 1) | BDBM2017 (2-(4-Azaindol-3-yl)-5,11-dihydro-11-ethyl-5-methyl...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 40: 2430-3 (1997) Article DOI: 10.1021/jm960837y BindingDB Entry DOI: 10.7270/Q2P26W9K | |||||||||||
More data for this Ligand-Target Pair |