BDBM202231 6-chloro-n,n-dimethyl-2-(2-(6-(2-methylpyrrolidin-1-yl)pyridin-2-yl)ethyl)quinazolin-4-amine::US9540384, 38

SMILES: CC1CCCN1c1cccc(CCc2nc(N(C)C)c3cc(Cl)ccc3n2)n1

InChI Key: InChIKey=ZOJRPJJGDXBJLU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 202231   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM202231 (6-chloro-n,n-dimethyl-2-(2-(6-(2-methylpyrrolidin-...) Show SMILES CC1CCCN1c1cccc(CCc2nc(N(C)C)c3cc(Cl)ccc3n2)n1 Show InChI InChI=1S/C22H26ClN5/c1-15-6-5-13-28(15)21-8-4-7-17(24-21)10-12-20-25-19-11-9-16(23)14-18(19)22(26-20)27(2)3/h4,7-9,11,14-15H,5-6,10,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	25
Hoffmann-La Roche, Inc. US Patent					Assay Description The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...				US Patent US9540384 (2017) BindingDB Entry DOI: 10.7270/Q2HT2MG1
					More data for this Ligand-Target Pair