BDBM202277 5,8-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyrazine::US9540384, 51

SMILES: Cc1cnc(C)c2nc(CCc3cncc(n3)N3CCCC3)nn12

InChI Key: InChIKey=BRETULWUCTYGEY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 202277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM202277 (5,8-dimethyl-2-(2-(6-(pyrrolidin-1-yl)pyrazin-2-yl...) Show SMILES Cc1cnc(C)c2nc(CCc3cncc(n3)N3CCCC3)nn12 Show InChI InChI=1S/C17H21N7/c1-12-9-19-13(2)17-21-15(22-24(12)17)6-5-14-10-18-11-16(20-14)23-7-3-4-8-23/h9-11H,3-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	25
Hoffmann-La Roche, Inc. US Patent					Assay Description The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...				US Patent US9540384 (2017) BindingDB Entry DOI: 10.7270/Q2HT2MG1
					More data for this Ligand-Target Pair