BDBM202387 US10081606, Compound I-19::US9238629, I-19::US9765038, Compound I-19

SMILES: COc1ccccc1Nc1ncc(F)c(Oc2cccc(NC(=O)C=C)c2)n1

InChI Key: InChIKey=XSYRRKUEQTWUCQ-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 202387   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM202387 (US10081606, Compound I-19 | US9238629, I-19 | US97...) Show SMILES COc1ccccc1Nc1ncc(F)c(Oc2cccc(NC(=O)C=C)c2)n1 Show InChI InChI=1S/C20H17FN4O3/c1-3-18(26)23-13-7-6-8-14(11-13)28-19-15(21)12-22-20(25-19)24-16-9-4-5-10-17(16)27-2/h3-12H,1H2,2H3,(H,23,26)(H,22,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	25
Celgene Avilomics Research, Inc. US Patent					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...				US Patent US9238629 (2016) BindingDB Entry DOI: 10.7270/Q2P849Q7
					More data for this Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M) (Homo sapiens (Human))	BDBM202387 (US10081606, Compound I-19 | US9238629, I-19 | US97...) Show SMILES COc1ccccc1Nc1ncc(F)c(Oc2cccc(NC(=O)C=C)c2)n1 Show InChI InChI=1S/C20H17FN4O3/c1-3-18(26)23-13-7-6-8-14(11-13)28-19-15(21)12-22-20(25-19)24-16-9-4-5-10-17(16)27-2/h3-12H,1H2,2H3,(H,23,26)(H,22,24,25)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	25
Celgene Avilomics Research, Inc. US Patent					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...				US Patent US9238629 (2016) BindingDB Entry DOI: 10.7270/Q2P849Q7
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (T790M/L858R) (Homo sapiens (Human))	BDBM202387 (US10081606, Compound I-19 | US9238629, I-19 | US97...) Show SMILES COc1ccccc1Nc1ncc(F)c(Oc2cccc(NC(=O)C=C)c2)n1 Show InChI InChI=1S/C20H17FN4O3/c1-3-18(26)23-13-7-6-8-14(11-13)28-19-15(21)12-22-20(25-19)24-16-9-4-5-10-17(16)27-2/h3-12H,1H2,2H3,(H,23,26)(H,22,24,25)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent									US Patent US9765038 (2017) BindingDB Entry DOI: 10.7270/Q26D5W3M
					More data for this Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M) (Homo sapiens (Human))	BDBM202387 (US10081606, Compound I-19 | US9238629, I-19 | US97...) Show SMILES COc1ccccc1Nc1ncc(F)c(Oc2cccc(NC(=O)C=C)c2)n1 Show InChI InChI=1S/C20H17FN4O3/c1-3-18(26)23-13-7-6-8-14(11-13)28-19-15(21)12-22-20(25-19)24-16-9-4-5-10-17(16)27-2/h3-12H,1H2,2H3,(H,23,26)(H,22,24,25)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	n/a
Celgene CAR LLC US Patent					Assay Description The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...				US Patent US10081606 (2018) BindingDB Entry DOI: 10.7270/Q2HH6N3X
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM202387 (US10081606, Compound I-19 | US9238629, I-19 | US97...) Show SMILES COc1ccccc1Nc1ncc(F)c(Oc2cccc(NC(=O)C=C)c2)n1 Show InChI InChI=1S/C20H17FN4O3/c1-3-18(26)23-13-7-6-8-14(11-13)28-19-15(21)12-22-20(25-19)24-16-9-4-5-10-17(16)27-2/h3-12H,1H2,2H3,(H,23,26)(H,22,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...				US Patent US9765038 (2017) BindingDB Entry DOI: 10.7270/Q26D5W3M
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM202387 (US10081606, Compound I-19 | US9238629, I-19 | US97...) Show SMILES COc1ccccc1Nc1ncc(F)c(Oc2cccc(NC(=O)C=C)c2)n1 Show InChI InChI=1S/C20H17FN4O3/c1-3-18(26)23-13-7-6-8-14(11-13)28-19-15(21)12-22-20(25-19)24-16-9-4-5-10-17(16)27-2/h3-12H,1H2,2H3,(H,23,26)(H,22,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	7.5	n/a
Celgene CAR LLC US Patent					Assay Description The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...				US Patent US10081606 (2018) BindingDB Entry DOI: 10.7270/Q2HH6N3X
					More data for this Ligand-Target Pair