BDBM203283 US10227340, Example 3::US9242975, 3

SMILES: CC(C)Nc1cc(Nc2ccc3nsnc3c2)ncc1-c1nnc(s1)C(=O)N1CC[C@@H](O)C1

InChI Key: InChIKey=JSADXPHJQCCHLN-CYBMUJFWSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 203283   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM203283 (US10227340, Example 3 | US9242975, 3) Show SMILES CC(C)Nc1cc(Nc2ccc3nsnc3c2)ncc1-c1nnc(s1)C(=O)N1CC[C@@H](O)C1 Show InChI InChI=1S/C21H22N8O2S2/c1-11(2)23-16-8-18(24-12-3-4-15-17(7-12)28-33-27-15)22-9-14(16)19-25-26-20(32-19)21(31)29-6-5-13(30)10-29/h3-4,7-9,11,13,30H,5-6,10H2,1-2H3,(H2,22,23,24)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Neuroscience					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...				J Med Chem 51: 1719-29 (2008) BindingDB Entry DOI: 10.7270/Q29C70Q8
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM203283 (US10227340, Example 3 | US9242975, 3) Show SMILES CC(C)Nc1cc(Nc2ccc3nsnc3c2)ncc1-c1nnc(s1)C(=O)N1CC[C@@H](O)C1 Show InChI InChI=1S/C21H22N8O2S2/c1-11(2)23-16-8-18(24-12-3-4-15-17(7-12)28-33-27-15)22-9-14(16)19-25-26-20(32-19)21(31)29-6-5-13(30)10-29/h3-4,7-9,11,13,30H,5-6,10H2,1-2H3,(H2,22,23,24)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.2	25
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substrates...				US Patent US9242975 (2016) BindingDB Entry DOI: 10.7270/Q2MC8XVD
					More data for this Ligand-Target Pair