BDBM203302 US10227340, Example 143::US9242975, 143

SMILES: CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(o1)-c1ccc(F)c(c1)S(=O)(=O)NC(C)(C)C

InChI Key: InChIKey=HQVPIXYBXXGIGM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 203302   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM203302 (US10227340, Example 143 | US9242975, 143) Show SMILES CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(o1)-c1ccc(F)c(c1)S(=O)(=O)NC(C)(C)C Show InChI InChI=1S/C27H28FN7O3S2/c1-15(2)31-21-12-24(32-17-7-9-20-22(11-17)39-14-30-20)29-13-18(21)26-34-33-25(38-26)16-6-8-19(28)23(10-16)40(36,37)35-27(3,4)5/h6-15,35H,1-5H3,(H2,29,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	676	n/a	n/a	n/a	n/a	n/a	n/a
Neuroscience					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...				J Med Chem 51: 1719-29 (2008) BindingDB Entry DOI: 10.7270/Q29C70Q8
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM203302 (US10227340, Example 143 | US9242975, 143) Show SMILES CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nnc(o1)-c1ccc(F)c(c1)S(=O)(=O)NC(C)(C)C Show InChI InChI=1S/C27H28FN7O3S2/c1-15(2)31-21-12-24(32-17-7-9-20-22(11-17)39-14-30-20)29-13-18(21)26-34-33-25(38-26)16-6-8-19(28)23(10-16)40(36,37)35-27(3,4)5/h6-15,35H,1-5H3,(H2,29,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	676	n/a	n/a	n/a	n/a	7.2	25
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substrates...				US Patent US9242975 (2016) BindingDB Entry DOI: 10.7270/Q2MC8XVD
					More data for this Ligand-Target Pair