BDBM203415 US9539260, B71::US9763952, Example B71

SMILES: CS(=O)(=O)c1ncc(cc1CF)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12

InChI Key: InChIKey=UESMRHDKASVKQQ-NRFANRHFSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 203415   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM203415 (US9539260, B71 | US9763952, Example B71) Show SMILES CS(=O)(=O)c1ncc(cc1CF)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12 |r| Show InChI InChI=1S/C25H30FN3O6S/c1-36(31,32)24-18(14-26)12-19(15-27-24)29-8-11-34-23-3-2-20(13-22(23)29)35-21-4-7-28(16-21)25(30)17-5-9-33-10-6-17/h2-3,12-13,15,17,21H,4-11,14,16H2,1H3/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...				US Patent US9539260 (2017) BindingDB Entry DOI: 10.7270/Q2W37TH1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM203415 (US9539260, B71 | US9763952, Example B71) Show SMILES CS(=O)(=O)c1ncc(cc1CF)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12 |r| Show InChI InChI=1S/C25H30FN3O6S/c1-36(31,32)24-18(14-26)12-19(15-27-24)29-8-11-34-23-3-2-20(13-22(23)29)35-21-4-7-28(16-21)25(30)17-5-9-33-10-6-17/h2-3,12-13,15,17,21H,4-11,14,16H2,1H3/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent									US Patent US9763952 (2017) BindingDB Entry DOI: 10.7270/Q2V40X9Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM203415 (US9539260, B71 | US9763952, Example B71) Show SMILES CS(=O)(=O)c1ncc(cc1CF)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12 |r| Show InChI InChI=1S/C25H30FN3O6S/c1-36(31,32)24-18(14-26)12-19(15-27-24)29-8-11-34-23-3-2-20(13-22(23)29)35-21-4-7-28(16-21)25(30)17-5-9-33-10-6-17/h2-3,12-13,15,17,21H,4-11,14,16H2,1H3/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The final concentrations of ATP and p...				US Patent US9763952 (2017) BindingDB Entry DOI: 10.7270/Q2V40X9Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM203415 (US9539260, B71 | US9763952, Example B71) Show SMILES CS(=O)(=O)c1ncc(cc1CF)N1CCOc2ccc(O[C@H]3CCN(C3)C(=O)C3CCOCC3)cc12 |r| Show InChI InChI=1S/C25H30FN3O6S/c1-36(31,32)24-18(14-26)12-19(15-27-24)29-8-11-34-23-3-2-20(13-22(23)29)35-21-4-7-28(16-21)25(30)17-5-9-33-10-6-17/h2-3,12-13,15,17,21H,4-11,14,16H2,1H3/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...				US Patent US9539260 (2017) BindingDB Entry DOI: 10.7270/Q2W37TH1
					More data for this Ligand-Target Pair