BDBM20383 1-isoquinolin-5-yl-3-{1-[4-(trifluoromethyl)phenyl]ethyl}urea::CHEMBL389715::isoquinoline antagonist, 5a

SMILES: CC(NC(=O)Nc1cccc2cnccc12)c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=FIRXVLDQHKDDGB-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 20383   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20383 (1-isoquinolin-5-yl-3-{1-[4-(trifluoromethyl)phenyl...) Show SMILES CC(NC(=O)Nc1cccc2cnccc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C19H16F3N3O/c1-12(13-5-7-15(8-6-13)19(20,21)22)24-18(26)25-17-4-2-3-14-11-23-10-9-16(14)17/h2-12H,1H3,(H2,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux				J Med Chem 51: 392-5 (2008) Article DOI: 10.1021/jm701007g BindingDB Entry DOI: 10.7270/Q218367F
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM20383 (1-isoquinolin-5-yl-3-{1-[4-(trifluoromethyl)phenyl...) Show SMILES CC(NC(=O)Nc1cccc2cnccc12)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C19H16F3N3O/c1-12(13-5-7-15(8-6-13)19(20,21)22)24-18(26)25-17-4-2-3-14-11-23-10-9-16(14)17/h2-12H,1H3,(H2,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...				Bioorg Med Chem Lett 17: 3894-9 (2007) Article DOI: 10.1016/j.bmcl.2007.04.105 BindingDB Entry DOI: 10.7270/Q2NV9GH2
					More data for this Ligand-Target Pair