BDBM204827 US9546168, ex 28
SMILES: CC(C)(O)[C@@H](NC(=O)Nc1cc2[nH]nc(c2c(CO)n1)C(C)(F)F)c1ccccc1
InChI Key:
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM204827 (US9546168, ex 28) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC.sub.50) of each compound was... | US Patent US9546168 (2017) BindingDB Entry DOI: 10.7270/Q2C24TM7 | |||||||||||
More data for this Ligand-Target Pair |