null

SMILES: CCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(cnc3-c3ccc(C)cc3)C(F)(F)F)cn2)cc1

InChI Key: InChIKey=UFEAYYJBORUWKT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 204830   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) (Homo sapiens (Human))	BDBM204830 (US9242977, 23) Show SMILES CCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(cnc3-c3ccc(C)cc3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C29H24F3N7O2S/c1-3-33-28-37-16-24(42-28)18-8-10-22(11-9-18)41-27-35-14-21(15-36-27)38-26(40)39-23-12-20(29(30,31)32)13-34-25(23)19-6-4-17(2)5-7-19/h4-16H,3H2,1-2H3,(H,33,37)(H2,38,39,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				US Patent US9242977 (2016) BindingDB Entry DOI: 10.7270/Q2639NJZ
					More data for this Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) (Homo sapiens (Human))	BDBM204830 (US9242977, 23) Show SMILES CCNc1ncc(s1)-c1ccc(Oc2ncc(NC(=O)Nc3cc(cnc3-c3ccc(C)cc3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C29H24F3N7O2S/c1-3-33-28-37-16-24(42-28)18-8-10-22(11-9-18)41-27-35-14-21(15-36-27)38-26(40)39-23-12-20(29(30,31)32)13-34-25(23)19-6-4-17(2)5-7-19/h4-16H,3H2,1-2H3,(H,33,37)(H2,38,39,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	7.5	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...				US Patent US9242977 (2016) BindingDB Entry DOI: 10.7270/Q2639NJZ
					More data for this Ligand-Target Pair