null

SMILES: Cc1ccccc1-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(F)F

InChI Key: InChIKey=XWLGFOFXYSCKFD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 204844   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) (Homo sapiens (Human))	BDBM204844 (US9242977, 72-3) Show SMILES Cc1ccccc1-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(F)F Show InChI InChI=1S/C30H26F2N8O3S/c1-18-6-3-4-7-22(18)40-25(14-24(38-40)30(2,31)32)37-27(42)36-20-15-33-28(34-16-20)43-21-11-9-19(10-12-21)23-17-35-29(44-23)39-13-5-8-26(39)41/h3-4,6-7,9-12,14-17H,5,8,13H2,1-2H3,(H2,36,37,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				US Patent US9242977 (2016) BindingDB Entry DOI: 10.7270/Q2639NJZ
					More data for this Ligand-Target Pair
Isoform TrkA-I of High affinity nerve growth factor receptor (TrkAI) (Homo sapiens (Human))	BDBM204844 (US9242977, 72-3) Show SMILES Cc1ccccc1-n1nc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cnc(s2)N2CCCC2=O)nc1)C(C)(F)F Show InChI InChI=1S/C30H26F2N8O3S/c1-18-6-3-4-7-22(18)40-25(14-24(38-40)30(2,31)32)37-27(42)36-20-15-33-28(34-16-20)43-21-11-9-19(10-12-21)23-17-35-29(44-23)39-13-5-8-26(39)41/h3-4,6-7,9-12,14-17H,5,8,13H2,1-2H3,(H2,36,37,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	7.5	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description TrkA-inhibiting activity was measured according to the following method using LanthaScreen kinase assay reagents (Invitrogen; Fluorescein-Poly GT, La...				US Patent US9242977 (2016) BindingDB Entry DOI: 10.7270/Q2639NJZ
					More data for this Ligand-Target Pair