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SMILES: CN(CCOc1cccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)n1)C(=O)C=C

InChI Key: InChIKey=CTPGSZLYOYCJJJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 206361   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM206361
PNG
(US9260415, 112)
Show SMILES CN(CCOc1cccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)n1)C(=O)C=C
Show InChI InChI=1S/C35H39N7O5/c1-6-31(44)39(4)14-15-47-30-9-7-8-29(38-30)37-26-16-23(20-40(5)33(26)45)24-10-11-36-32(25(24)21-43)42-13-12-41-27(34(42)46)17-22-18-35(2,3)19-28(22)41/h6-11,16-17,20,43H,1,12-15,18-19,21H2,2-5H3,(H,37,38)
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PC cid
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UniChem
US Patent
 1.75n/an/an/an/an/an/a7.5n/a



Genentech, Inc.

US Patent


Assay Description
A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...

US Patent US9260415 (2016)


BindingDB Entry DOI: 10.7270/Q2WH2NT7
More data for this
Ligand-Target Pair