BDBM20653 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-N-(2-methoxyethyl)-5-methylpyrrolo[1,2-a][1,2,4]triazine-6-carboxamide::pyrrolo[2,1-f][1,2,4]triazine analogue, 11f

SMILES: COCCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C

InChI Key: InChIKey=VKGYABXJZAASHG-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20653   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM20653 (4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-N-(...) Show SMILES COCCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C Show InChI InChI=1S/C20H24N6O4/c1-12-5-6-14(19(27)25-30-4)9-16(12)24-18-17-13(2)15(10-26(17)23-11-22-18)20(28)21-7-8-29-3/h5-6,9-11H,7-8H2,1-4H3,(H,21,28)(H,25,27)(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	140	n/a	n/a	7.5	22
Novartis Pharmaceuticals					Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...				J Med Chem 51: 4-16 (2008) Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB
					More data for this Ligand-Target Pair