BDBM207564 US10501467, Example 9::US9260440, 9::US9617273, Example 9

SMILES: CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O

InChI Key: InChIKey=MHQFEYXRRZRKBA-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 207564   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM207564 (US10501467, Example 9 | US9260440, 9 | US9617273, ...) Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	8.0	n/a
BeiGene, Ltd. US Patent					Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...				US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 3 (PARP-3) (Homo sapiens (Human))	BDBM207564 (US10501467, Example 9 | US9260440, 9 | US9617273, ...) Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
BeiGene, Ltd. US Patent					Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...				US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM207564 (US10501467, Example 9 | US9260440, 9 | US9617273, ...) Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	203	n/a	n/a	n/a	n/a	n/a	n/a
BeiGene, Ltd. US Patent					Assay Description Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...				US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM207564 (US10501467, Example 9 | US9260440, 9 | US9617273, ...) Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
BeiGene, Ltd. US Patent					Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...				US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV
					More data for this Ligand-Target Pair
TPoly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM207564 (US10501467, Example 9 | US9260440, 9 | US9617273, ...) Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.03E+5	n/a	n/a	n/a	n/a	n/a	n/a
BEIGENE, LTD. US Patent					Assay Description Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...				US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM207564 (US10501467, Example 9 | US9260440, 9 | US9617273, ...) Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.03E+5	n/a	n/a	n/a	n/a	n/a	n/a
BeiGene, Ltd. US Patent					Assay Description Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...				US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM207564 (US10501467, Example 9 | US9260440, 9 | US9617273, ...) Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
BEIGENE, LTD. US Patent					Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...				US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP3 (Homo sapiens (Human))	BDBM207564 (US10501467, Example 9 | US9260440, 9 | US9617273, ...) Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a
BEIGENE, LTD. US Patent					Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...				US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5
					More data for this Ligand-Target Pair
B-RAF V600E (Homo sapiens (Human))	BDBM207564 (US10501467, Example 9 | US9260440, 9 | US9617273, ...) Show SMILES CC1(C)Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C15H14FN3O/c1-15(2)5-10-13-11(6-15)18-19-14(20)8-3-7(16)4-9(17-10)12(8)13/h3-4,17H,5-6H2,1-2H3,(H,19,20)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a
BeiGene, Ltd. US Patent					Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...				US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV
					More data for this Ligand-Target Pair