BDBM207596 US10501467, Example 41::US9260440, 41::US9617273, Example 41
SMILES: CC1(C)Cc2n(CC3CO3)c3cccc4c3c2c(C1)n[nH]c4=O
InChI Key:
Data: 9 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 8.0 | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba... | US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ... | US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long) (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ... | US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba... | US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ... | US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
BEIGENE, LTD. US Patent | Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba... | US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
BEIGENE, LTD. US Patent | Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ... | US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein mono-ADP-ribosyltransferase PARP3 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
BEIGENE, LTD. US Patent | Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ... | US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM207596 (US10501467, Example 41 | US9260440, 41 | US9617273...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ... | US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV | |||||||||||
More data for this Ligand-Target Pair |