BDBM207623 US10501467, Example 68::US9260440, 68::US9617273, Example 68
SMILES: C[C@]12CCCN1Cc1n[nH]c(=O)c3cccc4[nH]c2c1c34
InChI Key: InChIKey=FFJICSMRLYFXCA-MRXNPFEDSA-N
Data: 9 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 8.0 | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba... | US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ... | US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS... | US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba... | US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ... | US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
BEIGENE, LTD. US Patent | Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba... | US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
BEIGENE, LTD. US Patent | Assay Description PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ... | US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TPoly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.22E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
BEIGENE, LTD. US Patent | Assay Description Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS... | US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM207623 (US10501467, Example 68 | US9260440, 68 | US9617273...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.22E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd. US Patent | Assay Description Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS... | US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV | |||||||||||
More data for this Ligand-Target Pair |