BDBM207985 4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-5-hydroxy-1,5-dihydro-2H-furan-2-one (2b)
SMILES: OC1(Cc2ccc(Cl)cc2)OC(=O)C(=C1Cc1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
InChI Key:
Data: 2 Kd
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Mdm2 (Homo sapiens (Human)) | BDBM207985 (4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | 7.4 | 25 |
Jagiellonian University | Assay Description MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W... | ACS Chem Biol 11: 3310-3318 (2016) Article DOI: 10.1021/acschembio.6b00596 BindingDB Entry DOI: 10.7270/Q2K35SH2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mdm2 (Homo sapiens (Human)) | BDBM207985 (4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 8.60E+4 | n/a | n/a | n/a | 7.4 | 15 |
Jagiellonian University | Assay Description Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi... | ACS Chem Biol 11: 3310-3318 (2016) Article DOI: 10.1021/acschembio.6b00596 BindingDB Entry DOI: 10.7270/Q2K35SH2 | |||||||||||
More data for this Ligand-Target Pair |