BDBM208106 US9265773, 49
SMILES: CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2OCn3c(cc4cccnc34)-c2c1)-c1ccc(F)cc1
InChI Key: InChIKey=CALNZTUXTIAFIP-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NS3 serine protease (NS3) (Hepatitis C Virus (Virus)) | BDBM208106 (US9265773, 49) | PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent | Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m... | US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HCV NS3-NS4A Serine Proteinase (Hepatitis C virus (HCV genotype 1a, isolate H)) | BDBM208106 (US9265773, 49) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.; MSD Italia S.R.L. US Patent | Assay Description Measurement of inhibition by compounds was performed using the HCV replicon system. Several different replicons encoding different HCV genotypes or m... | US Patent US9265773 (2016) BindingDB Entry DOI: 10.7270/Q2XD10H7 | |||||||||||
More data for this Ligand-Target Pair |