BDBM20874 3-{2-[(benzenesulfinyl)methyl]-1,3-thiazol-4-yl}-1,2-dihydroquinolin-2-one::quinolin-2(1H)-one derivative, (+/-)17p

SMILES: O=S(Cc1nc(cs1)-c1cc2ccccc2[nH]c1=O)c1ccccc1

InChI Key: InChIKey=UQSJZZMWPULVAA-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20874   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM20874 (3-{2-[(benzenesulfinyl)methyl]-1,3-thiazol-4-yl}-1...) Show SMILES O=S(Cc1nc(cs1)-c1cc2ccccc2[nH]c1=O)c1ccccc1 Show InChI InChI=1S/C19H14N2O2S2/c22-19-15(10-13-6-4-5-9-16(13)21-19)17-11-24-18(20-17)12-25(23)14-7-2-1-3-8-14/h1-11H,12H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair