BDBM20879 C-aryl glucoside, 5::CHEMBL429911::N-ethyl-2,6-dihydroxy-5-[(4-methoxyphenyl)methyl]-3-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]benzamide

SMILES: CCNC(=O)c1c(O)c(Cc2ccc(OC)cc2)cc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1O

InChI Key: InChIKey=ZXQPEYYMUBKGOA-JLMLEOCNSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 20879   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM20879 (C-aryl glucoside, 5 | CHEMBL429911 | N-ethyl-2,6-d...) Show SMILES CCNC(=O)c1c(O)c(Cc2ccc(OC)cc2)cc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1O Show InChI InChI=1S/C23H29NO9/c1-3-24-23(31)16-17(26)12(8-11-4-6-13(32-2)7-5-11)9-14(18(16)27)22-21(30)20(29)19(28)15(10-25)33-22/h4-7,9,15,19-22,25-30H,3,8,10H2,1-2H3,(H,24,31)/t15-,19-,20+,21-,22+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	7.2	22
Bristol-Myers Squibb Company					Assay Description Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...				J Med Chem 51: 1145-9 (2008) Article DOI: 10.1021/jm701272q BindingDB Entry DOI: 10.7270/Q2PN93X4
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM20879 (C-aryl glucoside, 5 | CHEMBL429911 | N-ethyl-2,6-d...) Show SMILES CCNC(=O)c1c(O)c(Cc2ccc(OC)cc2)cc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1O Show InChI InChI=1S/C23H29NO9/c1-3-24-23(31)16-17(26)12(8-11-4-6-13(32-2)7-5-11)9-14(18(16)27)22-21(30)20(29)19(28)15(10-25)33-22/h4-7,9,15,19-22,25-30H,3,8,10H2,1-2H3,(H,24,31)/t15-,19-,20+,21-,22+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co Curated by ChEMBL					Assay Description Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption				J Med Chem 52: 1785-94 (2009) Article DOI: 10.1021/jm8013019 BindingDB Entry DOI: 10.7270/Q2F47Q1T
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human))	BDBM20879 (C-aryl glucoside, 5 | CHEMBL429911 | N-ethyl-2,6-d...) Show SMILES CCNC(=O)c1c(O)c(Cc2ccc(OC)cc2)cc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1O Show InChI InChI=1S/C23H29NO9/c1-3-24-23(31)16-17(26)12(8-11-4-6-13(32-2)7-5-11)9-14(18(16)27)22-21(30)20(29)19(28)15(10-25)33-22/h4-7,9,15,19-22,25-30H,3,8,10H2,1-2H3,(H,24,31)/t15-,19-,20+,21-,22+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	>8.00E+3	n/a	n/a	7.2	22
Bristol-Myers Squibb Company					Assay Description Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...				J Med Chem 51: 1145-9 (2008) Article DOI: 10.1021/jm701272q BindingDB Entry DOI: 10.7270/Q2PN93X4
					More data for this Ligand-Target Pair