BDBM209044 US9243038, 19

SMILES: NC(=O)C1CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC(=O)C(Cc2ccccc2)NC(=O)\C=C\C(=O)N1

InChI Key: InChIKey=NMKKGWJKVLDYGD-PZVJSLTESA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 209044   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
insulin-degrading enzyme isoform 1 precursor (Homo sapiens (Human))	BDBM209044 (US9243038, 19) Show SMILES NC(=O)C1CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC(=O)C(Cc2ccccc2)NC(=O)\C=C\C(=O)N1 |r,t:56| Show InChI InChI=1S/C44H52N6O7/c45-41(54)34-18-10-11-25-46-42(55)35(28-31-19-21-33(22-20-31)40(53)32-16-8-3-9-17-32)49-44(57)37(27-30-14-6-2-7-15-30)50-43(56)36(26-29-12-4-1-5-13-29)48-39(52)24-23-38(51)47-34/h1,3-5,8-9,12-13,16-17,19-24,30,34-37H,2,6-7,10-11,14-15,18,25-28H2,(H2,45,54)(H,46,55)(H,47,51)(H,48,52)(H,49,57)(H,50,56)/b24-23+/t34?,35-,36?,37+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
President and Fellows of Harvard College US Patent					Assay Description Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...				US Patent US9243038 (2016) BindingDB Entry DOI: 10.7270/Q2MW2FZV
					More data for this Ligand-Target Pair